Wednesday, September 8, 2010

The smart pill against cancer

The smart pill against cancer


With video pills to cancer had been diagnosed only. The iPill drugs will in future be released selectively in the digestive tract to help on the spot.



More than six percent of all Germans suffer in their lives to cancer. The prognosis for malignant tumors can be diagnosed early, by colonoscopy and pills video traveling through the digestive tract. Now is a smart pill, called iPill also improve the treatment of the disease directly in the gut. A first prototype of Dutch developer to present this week at the annual meeting of the American Association of Pharmaceutical Scientists in Atlanta, Georgia.


"A technology like the iPill, which combines electronics, diagnostics and therapy together, creates the opportunity to get almost any drug to any location in the digestive tract," says Henk van Houten, director of healthcare research at Philips Research in Eindhoven. With one sip of water the 26 millimeter long and can be about an inch thick capsule easy to swallow.


In her mind to hide a drug container, a mini-pump, temperature and acid sensor, a microprocessor, a battery and a radio module. Thus equipped, the pill is based on the basis of acidity in the stomach or intestine. They reached the affected region, it can selectively release a drug, for example, to treat a cancer.


Data about the location, pH The pH is a measure of the acidity or alkalinity of an aqueous solution. The value of 7 corresponds to pure Wasseroder a neutral solution. All that lies beneath it is sour. Solutions with a pH value that is greater than 7 are alkaline or alkaline. Battery acid is below the value 0 and is thus one of the most acidic solutions. Lemon juice (2.4) and wine (4.0) are also included in this group. However, blood alkaline (7.4), or soap (9.0) are. And temperature can mean the radio module using the RFIDRadio Frequency Identification as much as identification with the help of electromagnetic Wellen. technology out of the body to send to the doctor. An even more precise tracking is possible with X-ray or magnetic resonance images. The capsule has unloaded its cargo intact, it is excreted by the natural digestion process again.


So far, the scientists tested their intelligent capsule in laboratory models. Before use in patients soon could further animal studies and clinical trials follow. Not only against cancer is to these transporters are used, the treatment of Crohn's Disease This is a chronic, inflammatory autoimmune disease of the digestive tract, which affects mainly the small and large intestine. Crohn's disease usually occurs at age 15-34 years, and is not curable. Symptoms include frequent diarrhea, pain in the lower right abdomen, fever, loss of appetite and general malaise. and inflammatory bowel disease (ulcerative UlcerosaDise chronic disease affects the colon, where inflammatory ulcers can. Typical symptoms are bloody stools, diarrhea and abdominal pain. mainly affects adults aged 20-40 years.), the developers have in mind. As might act directly in the intestinal medicines in smaller doses more effective, are also not yet possible to imagine therapies.


"The combination of good location determination, electronically controlled release of drugs and on the way through the digestive tract of collected data, making the" iPill a valuable tool in drug development, says Karsten Cremer of the pharmaceutical companies Concepts in Basel.



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The smart pill against cancer