The smart pill against cancer

The smart pill against cancer

With video pills to cancer had been diagnosed only. The iPill drugs will in future be released selectively in the digestive tract to help on the spot.

More than six percent of all Germans suffer in their lives to cancer. The prognosis for malignant tumors can be diagnosed early, by colonoscopy and pills video traveling through the digestive tract. Now is a smart pill, called iPill also improve the treatment of the disease directly in the gut. A first prototype of Dutch developer to present this week at the annual meeting of the American Association of Pharmaceutical Scientists in Atlanta, Georgia.

"A technology like the iPill, which combines electronics, diagnostics and therapy together, creates the opportunity to get almost any drug to any location in the digestive tract," says Henk van Houten, director of healthcare research at Philips Research in Eindhoven. With one sip of water the 26 millimeter long and can be about an inch thick capsule easy to swallow.

In her mind to hide a drug container, a mini-pump, temperature and acid sensor, a microprocessor, a battery and a radio module. Thus equipped, the pill is based on the basis of acidity in the stomach or intestine. They reached the affected region, it can selectively release a drug, for example, to treat a cancer.

Data about the location, pH The pH is a measure of the acidity or alkalinity of an aqueous solution. The value of 7 corresponds to pure Wasseroder a neutral solution. All that lies beneath it is sour. Solutions with a pH value that is greater than 7 are alkaline or alkaline. Battery acid is below the value 0 and is thus one of the most acidic solutions. Lemon juice (2.4) and wine (4.0) are also included in this group. However, blood alkaline (7.4), or soap (9.0) are. And temperature can mean the radio module using the RFIDRadio Frequency Identification as much as identification with the help of electromagnetic Wellen. technology out of the body to send to the doctor. An even more precise tracking is possible with X-ray or magnetic resonance images. The capsule has unloaded its cargo intact, it is excreted by the natural digestion process again.

So far, the scientists tested their intelligent capsule in laboratory models. Before use in patients soon could further animal studies and clinical trials follow. Not only against cancer is to these transporters are used, the treatment of Crohn's Disease This is a chronic, inflammatory autoimmune disease of the digestive tract, which affects mainly the small and large intestine. Crohn's disease usually occurs at age 15-34 years, and is not curable. Symptoms include frequent diarrhea, pain in the lower right abdomen, fever, loss of appetite and general malaise. and inflammatory bowel disease (ulcerative UlcerosaDise chronic disease affects the colon, where inflammatory ulcers can. Typical symptoms are bloody stools, diarrhea and abdominal pain. mainly affects adults aged 20-40 years.), the developers have in mind. As might act directly in the intestinal medicines in smaller doses more effective, are also not yet possible to imagine therapies.

"The combination of good location determination, electronically controlled release of drugs and on the way through the digestive tract of collected data, making the" iPill a valuable tool in drug development, says Karsten Cremer of the pharmaceutical companies Concepts in Basel.

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The smart pill against cancer

Paralyzed man can again "talk"

Paralyzed man can again "talk"

U.S. researchers have a completely paralyzed man returned a piece of his linguistic abilities. Thanks to a speech used in the electrode, the patient can produce more than one computer three vowels - as he thinks of the lute.

The man suffers from a Locked-In Syndrome. Normally, people can move up to their eyeballs with this syndrome or eyelids, and communicate so that neither muscle contractions even over their vocal apparatus. With the new system had now been constructed for the first time an interface between the brain and electronics that converts brain signals directly in language, study leader Frank Guenther of Boston University reported at the annual meeting of the American Society for Neuroscience in Washington.

Most brain-computer interface (BCI) detect brain waves through electrodes that are placed outside the skull. They are currently used primarily to enable people after the loss of limbs a mental control of their prostheses and to give a lame way to use a computer cursor. However, at this system, the electrodes move quite easily - with the consequence that they measure the wrong signals and the BCI to be recalibrated.

Because Guenther and his team, however, wanted to permanently absorb the impulses, controls the speech with which the vocal tract, they implanted their patients an electrode directly into the appropriate brain region. The part was so impregnated, that it promoted the growth of nerves and a long and more firmly anchored in the brain.

After surgery, the researchers in the subjects specifically thinking about certain vowels, and drew attention to the signals recorded by the electrode. This was then fed into a computer with a connected synthesizer and associated with the vowel. In this way produces the computer every time the man thinks about an "A" without delay the sound "A".

Meanwhile, the patient thus already three vowel sounds create a high accuracy and a speed equal that of normal speech, reported Guenther. Long-term - estimated in the next five years - is the subject learn to produce consonants, and these combine with the vowels to complete words. Guenther also hopes to record in similar cases in future, thanks to enhanced technology more details of brain activity to be able, for example by the transplanting of several electrodes.

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Apple CEO wants his rest

Apple CEO wants his rest

Apple CEO Steve Jobs wants to do, despite the claims of investors and industry experts, no further details about his health. "Why do you guys let me in peace - why is this so important?" Jobs said in a rare interview.

To have the health of the 53-year-olds for months much attention because he is regarded as the driving force behind the success of the computer and iPhone manufacturer Apple. Jobs announced a few days ago that he would take a break because of his health problems until the end of June, as the treatment is more complex than first thought. According to recent information he is suffering from a hormonal disorder.

The financial news agency Bloomberg, led the interview with the jobs reported, also citing people that Jobs' health watch ", of consideration of a liver transplant. It remained unclear, however, whether it's about people who actually are familiar with the disease of the Apple boss, or to experts who analyze his condition remotely.

After Jobs' information prevents the hormone disorder because his body to process proteins, making it lose weight. In 2004, Jobs was due to a cancer tumor, had surgery on the pancreas. It was modified several times, he did not have cancer.

Since June 2008 the first time noticed the weight loss of jobs, the information from Apple is criticized. The company was making a slow and only very general information about Jobs' health. Many investors and industry experts are calling, however, that Apple fully informed, given the prominent role of the co-founder of the Group's business on his health. In this context, shareholder suits are not excluded. The constantly emerging speculation about Jobs' health had impacted the price of Apple shares in recent months strong.

Jobs is like no other U.S. managers as a motor and guarantor of the success of his group. Apple's triumph in recent years with products like the iPod music player and iPhone mobile attributed to a large job. He will remain involved during the time out on important strategic decisions, the charismatic corporate executives said several days ago. He will be soon be re-elected in the Board of the Disney Corporation, where he has been the sale of Pixar Animation Studios has a share of 7.5 percent.

In the coming months is to Tim Cook, Apple's take on the reins. Cook is considered one of the main architects of the economic success of the computer and iPhone manufacturer. As for the daily business responsible, "Chief Operating Officer, he ensures that after the implementation of bold visions at the end of the day in the black are in the books. And with success: Apple is sitting on cash reserves of almost 25 billion U.S. dollars - with no debt. The U.S. magazine Fortune recently paid tribute to Cook as "the genius behind Steve. The next few months would show whether the 48-year-old Cook had grown too long, perhaps the chief role at Apple.

Jobs took the Compaq-manager in 1998 for Apple - and Cook took on the then-struggling company by quickly with efficiency. He closed his own manufacturing plants, Apple, and put on contract manufacturers. He left the stocks of months melt to days. The Apple later helped again and again to have lying around in the fast model changes in the electronics industry does not run as legacy devices. Cook the same time ensured smooth delivery of the various products. Most recently he was responsible for the lead among other business with the success of the iPhone mobile phone.

Similar to the 53-year-old Cook jobs is regarded as publicity-shy workaholic who sends e-mails and sometimes in the middle of the night - and often as difficult to work with. Cook's management style illustrated by the following anecdote from the Fortune 90s. Apple Cook-Manager advise about a problem in Asia. "That's bad, he says. Someone should be immediately worry about in China. "Half an hour later, he looks one of those present in the face and asks:" Why are you still here? ". The manager goes directly to the airport and buy a ticket without a definite return date.

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Schaeffler warn of destruction

Schaeffler warn of destruction

Breaking up the Schaeffler-Continental Group, according to the owner family could cost thousands of jobs in Germany. In addition, there were serious consequences for the global car production, said Georg Schaeffler.

In an advance notification of the Bild am Sonntag newspaper he is quoted as saying: "The network of the company creates with the high precision of the electronics of Conti and Schaeffler, a technological future. This kept thousands of highly skilled workers secure employment in Germany. "That could only work if given the unity of Schaeffler and Continental will stay.

His mother, businesswoman Maria-Elisabeth, told the paper, the joint company stand for an industrial substance that there is no world again and can not be easily replaced. "In any car in this world you will find an average of 60 parts only from the Schaeffler production. A disruption in our production for the automotive industry worldwide has serious implications. "

The company's owner pulled the report, investment bank Lehman Brothers parallels, whose collapse last year, the global financial crisis worsened. "A renowned consultancy has compared our importance to the industry with those of Lehman Brothers for the banking world."

Maria-Elisabeth Schaeffler made it clear that the group was dependent on money from the state. Without a temporary bridge by the financial state it is difficult for the unity and future of Continental and Schaeffler. "The function of the taxpayers they meet in person. "It is important however that the company will pay back everything with interest to the last penny. It is not a gift. "

The Frankish family business wants to take over the larger Hanover Group Continental, but because of the financial crisis and economic difficulties. Worldwide, every major car manufacturer massive decline in orders, which has a direct impact on suppliers.

The Bavarian Minister Horst Seehofer (CSU) agreed to help for Schaeffler, but rejected direct participation. The state should help these companies if they had a sustainable approach and it stood the main banks of these companies, said the CSU chairman of the Cologne Stadt-Anzeiger.

This is about thousands of jobs. Then you can easily take over warranties and guarantees as the state and help to safeguard jobs. "The state should not directly operate as entrepreneurs, Seehofer was quoted as saying. "It is in human history has never gone well."

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The golden calf in our life

The golden calf in our life

The Cayenne is Porsche's cash cow. Now the gap has closed a Zuffenhausen in the program: The GTS attracts a particularly agile chassis and refined look. There is enough power - consumption too.

Whoever hears the name Porsche in Germany, who thinks of the 911. In Beijing, Moscow or Dubai but we think the Porsche Cayenne. The worldwide demand for the potent ground athlete does not stop. Every day, rolling in the Leipzig factory Porsche 180 Cayenne from the tape. not "More is the best will," says Porsche spokesman Christian Dau. Even the icy climate that sentiment run currently in Germany for the horsepower SUV, should not stop the success story worldwide.

For the Porsche Cayenne is used primarily as a door opener for lucrative new markets - Russia, China, Latin America, the Middle East. "Without the Cayenne's sales in these markets, we could not" open up as many centers Porsche says Dau. Only in the USA's sales have Ahlen join in on the previous year because of the local discount battle (in the Porsche is not out of principle) and the hike in fuel prices, receive a shock from minus ten percent.

After the Cayenne Turbo S was kicked out of the range model, the latest addition to the cash cow now moved among the current top model Cayenne Turbo (500 hp) and the Cayenne S (385 hp). The GTS has the same engine as the S (eight-cylinder engine with 4.8 liters of displacement), but makes 20 more horsepower and comes to 405 horsepower.

Porsche has increased among other things, the intake of the engine. There are a few extras optics (such as the martial front apron of the Turbo model, four tailpipes at the rear) and optional two exclusive paint finishes - "GTS Red" and the friendly "Nordic Gold".

The most important thing: The GTS is still more than his brothers trimmed to the pure road use. The wheel arches have been widened to the right and left by 14 mm, 21-inch wheels make any tuning unnecessary. And the GTS the asphalt is 24 mm nearer than the other models. For the first time in the GTS also the steel suspension of the Cayenne with Porsche's PASM adaptive chassis control combined.

The purpose of all these measures is the latest one "becomes clear when you look at the press release for the GTS once read through all: more than 60 times there is the word or word element" Sport "to read. Of course, the GTS has permanent four-wheel drive, including all high-tech helpers for the terrain. But it is made primarily for speed, despite its quick as 2.2 tons of curb weight to the corners.

And he can. The GTS is so tight with his calves on the asphalt like a 100-meter runner. The optional active roll stabilization, you can hunt the four-door Porsche as fast through the corners that you feel a bit like in the coming Panamera. GTS is a standard in the Sport button.

If you press it, you get the electronics to the commission to let it fly right time: the throttle, the engine characteristics and all control systems are brought to exercise class. This fits the precise six-speed circuit, with the Cayenne we always carried in a speed level where he feels comfortable.

When it comes to fuel consumption, there is a good and bad news. The good: The tank of the Cayenne is only 35 liters, 100 liters less than 911th of the trunk of a Porsche The bad: After 100 miles of city traffic GTS has already gesuffelt 22.6 liters of it empty. In the EU there are triple mix with manual transmission 15.1 liters.

No wonder that is independent of the forthcoming Cayenne Hybrid always listen to me the tentative demand for a diesel engine. A few years ago would probably still Porsche manager of blasphemy have been accused, they would have taken the D-word, even in the mouth. Today it is still: "We all drive each year options on the test. To expect" a Cayenne-ignition is more of not feeling well.

The Cayenne GTS will cost € 76 725 with about 10,000 euros more than a Cayenne S and is approximately 30,000 € cheaper than the Turbo. Standard equipment includes newly developed Twelve-way sport seats, which can be adjusted electrically. Even the rear passengers to take in figure-hugging stalls with increased side bolsters place, so that in the wild back-and not cornering herrutscht.

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Albums made of paper are not obsolete a long time

Albums made of paper are not obsolete a long time

Who has the choice, the agony is the in the production of photo books that are not inspiron 6000 battery only in Germany increasingly popular. The number of providers is steadily increasing, there are differences in the handle, the quality - and the price.

It's strange. In a world of increasing digitization conquered the market a product that has to do at first glance with the computerized data highway to apparently nothing: the photo album. No more endless slideshows on the PC, people want something in hand, scroll in which they can if they want to remember the last vacation or experiences from their childhood.

However, the photo book today has little to do with what the parents 'or grandparents' generation has designed for decades. The painstaking gluing hundreds of photos, handwritten captions, all that belongs to the past. Today, photo books on the inspiron 11z battery computer - either online or using special software programs are filled - professionally processed and finally sent in bound version of the client.

The great advantage of the books: Once created, can be ordered as many copies. The Internet portal golem.de that were sold in the U.S. alone last year, 12.5 million of these photo books. This year the industry expects there with sales of around 17 million units. Rising. But what to look for? Which of the many providers is the right one?

teltarif.de According to the online portal is a small photo books available from just eight euros. The amount of the cost depends on the size, scale and quality of the photo book. For good print quality photos in A4 format from a range of three-megapixel camera, which experts say Teltarif. However, also determine optics, image processing and imaging quality.

To create a book must be loaded in most cases, the first software provider to your own computer. This process is free. Then you can choose for the individual book pages templates and order his images according to the desired layout.

The finished photo book file with the digital images can either be sent via Internet to inspiron e1505 battery the provider or to burn the file to a CD and brings or sends it to the dealer. Burning a CD photo book is useful when your internet is not suitable for transferring large amounts of data.

Photo book offers can be found on the internet and in drugstores, electronics and food markets. The Stiftung Warentest last year took twelve o'clock provider under the microscope. Seven of them who had a hard cover (hardcover) in the offer, "cut me off." Even with four producers Softcover received the rating "good." All others had to deal with the grade "satisfactory resign."

The biggest differences in the test, according to the design, such as the number of layout templates, or possible background patterns of image processing options provided in the program. Generally, images should be stored Teltarif in jpg format, according to facilitate the imaging of the camera.

The delivery of each provider fluctuated. While some customers have their photo books inspiron 1501 battery after four days in the mailbox had, others had to wait sometimes up to two weeks. A look at the terms and conditions and delivery times is worthwhile

 

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The tiny unknown

Nanotechnology: The tiny unknown

Nanotechologien are already widely used. The particles enter through air, skin, water and food into the body. What the tiny par sony pcga-ac19v3.

Nano is the most revolutionary cry which has produced the technology in recent years. But before explaining how the small particles that are used in the various technologies used, have an impact on health, they have already found entry into everyday life. Very critical is the national institution and therefore has published a guide booklet, which grapples with the world of Tiny.

From Nano is spoken, if used materials are made of particles in the order of one to about 100 nanometers. Nanotechnologies are not uniform and therefore difficult to evaluate in general. They are used for example in computer technology, as tiny electronic component Chen, in coatings thinkpad x60 battery, such as automobile paints or sanitary facilities, but also in textiles, cosmetics and in foods and in products for children, such as pacifiers or toys.

The development has raised great hopes in medicine. The aim is among other nanoparticles act as an intelligent drugs and ferries to transport drugs directly into cancer or tumor tissue. has the side effects, today's drugs on the healthy tissue would disappear with it, hope.

But the problem is, the consumer advice that some substances in crude form, although harmless, subtle brought to the nanoscale, but this will be the violent reactions to light can. One reason is the enormous increase in surface area. But even the smallest particles out into the body slightly in cells or even enter the nucleus and changes cause confusion or cause cell processes.

Other reaction in nano-sized

Example, it is proven that although titanium dioxide in Grobform causes no damage. But nano-sized effect of a substance that is also often used in cosmetics, such as suntan lotions, toxic and could reach about small scratches in the skin into the body. There it can be liver, kidney and heart muscle damage and result in the destruction of genetic material in cells. Whether titanium dioxide but in a product or tiny rough occurs to the contents list is not visible. After all, the use of nanoparticles is not yet classified.

A grievance, which urgently needs to change, the Consumer calls in its brochure. "The existing laws should be adapted to nanomaterials as new substances, without exception, must" be treated and admitted, it said. Also had a lot more money flowing into risk research. Currently, the federal government promotes nanotechnology pcga-bp2nx battery with around 370 million € per year. Only a fraction was used for the study of impact on environment and health. This percentage should be increased to at least ten to 15 percent. To clarify the risk, children should receive special protection and nanotechnology to develop products subject to stringent limits for children.

Nanoparticles something from the clothing or washing machine technologies can, despite a relatively close relationship gets accidentally into the body where they detach from the material and be inhaled or landing in the water during the washing cycle. This concerns about nano-silver, the antibacterial effect, or the Nano-Tex technology, as used in jackets around the brand Jack Wolfskin and identified. There was also no adequate studies Nano-Tex, the dangers and risks to exclude conclusively how Jack Wolfskin communicates itself. Previous tests, however, would suggest that the technology is safe, the company said.

Risks and dangers, very little research

It had already been established that Nanosilberpartikel in the body can cause a damage to the liver and brain cells, says Professor Richard Raedsch the professional association of internal medicine. Most applications of nanotechnology and its impact on the environment and health are still studied.

In the food industry, nanoparticles can be used, for example, as flow aids for dried soups or spice mixtures and to prevent optical changes in chocolate. Of great importance is the addition of nanoparticles to stabilize them in both the product itself and in the packaging.

"Currently, there is for the consumer is not possible to detect whether nanomaterials in the manufacture of a product were used. However: The less a food has been processed industrially, the less likely it is that it was mixed with nanoparticles, "advises Raedsch. Only a few products are actually a nano-mark.

Further details for the use of nanotechnology are "additives such as textiles, household pcga-bp2ny battery appliances and products for children such as" antibacterial "or" germ-free, advises the Consumer. Also, there is now a nano product directory of the Woodrow Wilson Center. But that is far from complete and only available in English.

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